Duke Endowment disbursed $14.4 million to relief agencies in western North Carolina and Upstate South Carolina.
Other grantees include the United Way of Greenville County, S.C.
The Community Foundation of Western North Carolina received $5 million, while the One SC Fund received $3 million.
The American Red Cross received $1 million to support food and shelter needs.
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The Charities Aid Foundation has set up a scheme, called the Social Enterprise Assist, that will render interest-free loans of up to £10,000 each to help social enterprise start-ups.